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A burst in ROS production in mitochondria, most likely O 2 , would lead to oxidation of the glutathione pool and the subsequent S-glutathionylation of various proteins

Lip-1 Lip-1, a derivative of quinoxaline spirocyclic compounds, is a potent ferroptosis inhibitor first identified in 2014 through small molecule compound library screening (129)

significantly reduced the proliferation and collagen secretion of hypertrophic scar fibroblasts

The assessment of additional epigenetic and biochemical markers could also provide deeper insights into the observed differences between groups, ultimately contributing to the development of more effective and personalized intervention strategies